The kidneys are believed to be the most important organ in the human body in the fight against long-term fluoride exposure. Healthy adult kidneys are able to excrete about 50 percent of ingested fluoride and are responsible for preventing toxic levels of fluoride from accumulating in the body. However, adults who have kidney disease excrete about 10 to 20 percent of ingested fluoride, which increases their body burden of fluoride and increases their likelihood of fluoride poisoning.
http://www.assureasmile.com/miami-dentist-blog/fluoride-and-the-kidneys/
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