Research published in the January 2013 Journal of Nutritional Biochemistry explains that the major factor of obesity is not calories, but gluten. It says that weight gain from wheat consumption isn’t from the calories, but from the gluten proteins that disrupt the endocrine and exocrine systems in the body and alters metabolism causing weight gain. A gluten-free diet has been thought to prevent diseases like Celiac disease and obesity, but hadn’t been studied. Therefore, research was conducted on two sets of rats to compare a gluten-free diet to a gluten-based diet. Both groups were fed high-fat diets, but one group was fed 4.5 percent gluten while the other group was kept gluten free. Researchers then compared 16 different markers like body weight, insulin resistance and blood lipid profiles in both groups of rats.
http://www.assureasmile.com/miami-dentist-blog/does-gluten-cause-weight-gain/
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